EA 2622- Laboratory of cell and molecular genetics. 6 researchers.
Research topics:
Molecular Genetics and Cell Biology associated with Human Pathology.
Cystic Fibrosis:
- Study of proteins, such as syntaxin 8, that bind to the regulatory domain (R) of CFTR (Cystic fibrosis transmembrane conductance regulator).
- Clinical study of the relationship between asthma and CFTR mutations.
Chronic Myeloid Leukaemia:
- Comparison of Bcr-Abl transcription levels during the course of the illness and during treatment.
- Study of Bcr-Abl signal transduction to the actin cytoskeleton and to the Rho small G protein family.
Hemochromatosis and venous thrombosis: Genetic pathology associated with the Factors II & V.
Molecular evolution & cellular interactions:
- Study of the evolution of INK4a locus in primates.
- Study of the role through evolution of the residue threonine 31 in the function of the ARF protein.
- General study of evolution from molecular data available in primates.
Techniques and equipment of interest
- ABI PRISMR 7700 Sequence Detector.
- ABI PRISMR 310 Genetic Analyser.
- Fluorescent microscope linked to a video system.
- DGGE apparatus.
- HPLC |
