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RESEARCH 2006, September 19
 
Proteomics platform: The CHU strides ahead
 

 
Just like Grenoble and Toulouse, Poitiers Hospital (the CHU) is presently equipping itself with a first-class proteomics platform. Here are Jean-Louis Fauchère’s explanations.

It all started two years ago. Since 2004, the CHU biology pole has been going all out to bring one of the site’s projects into being: a proteomics platform – or rather, in Jean-Louis Fauchère’s words, a “proteome-genome platform”. The pole coordinator, who is in charge of the hospital’s bacteriology ward, at first addressed an application to local administrations, the university, and his own establishment. Positive echoes were few and far between, and that is essentially why Fauchère decided to “prime the pump” by investing in equipment permitting the “rough-hewing of biomarker searchers”.

“It is an apparatus that answers some needs of the medicine consisting in the systematic search of biomarkers from highly diversified human materials such as cancer cells, normal ones, sera…”, Jean-Louis Fauchère elaborates. The ultimate objective is to determine the profile of the proteins contained in these materials. Analysis of the human genome has indeed highlighted the role of proteins in the functioning and development of the human organism. This work could take place at Poitiers Hospital on account of “the large number of materials available, both pathogenic and healthy”.

A large-scale construction site

Elaboration of the proteins’ profiles consequently constitutes the platform’s initial stage. “After that, it shall be necessary to determine which proteins are the most interesting for a diagnosis, prognosis or therapeutic follow-up test. These tests enable us to say, in accordance with the biomarkers, whether the evolution is favorable or unfavorable”, Professor Fauchère goes on to indicate. It stands to reason that it will take a great deal of work to establish the correlation between observed clinical signs and the biological profiles observed thanks to proteomics techniques.

“Were we to get that far, we would be quite pleased…”, acknowledges the coordinator of the CHU biology pole. This is due to the fact that the next stage of the process (how does a normal cell come to be pathogenic?) necessitates “the labor of basic research”, which the hospital center lacks the wherewithal to underwrite. “We may dispose of data banks, notably via the Internet. What stops us is that we don’t quite know how to use them, and that the right apparatuses are lacking.”

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